Synthesis and biological evaluation of isatin derivatives containing 1,3,4-thiadiazole as potent a-glucosidase inhibitors
Xuelian Zhao, Xuehui Zhan, Huilin Zhang, Yichao Wan, Huizhong Yang, Yutian Wang, Yanda Chen, Wenlin Xie
Topics & Concepts
ChemistryResveratrolIsatinIC50StereochemistryQuantitative structure–activity relationshipEnzymeDocking (animal)In vitroActive siteStructure–activity relationshipEnzyme inhibitorBiological activityBiochemistryOrganic chemistryMedicineNursingSynthesis and biological activityBioactive Compounds and Antitumor AgentsCalcium signaling and nucleotide metabolism