Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway
Dan Li, Jiangping Xu, Yunyun Qin, Ningbo Cai, Yufang Cheng, Haitao Wang
Topics & Concepts
AMPKMicrogliaPhosphorylationCell biologyNeuroinflammationTumor necrosis factor alphaLipopolysaccharidePhosphodiesteraseHippocampusChemistryInflammationProtein kinase AMedicineEndocrinologyInternal medicineBiologyBiochemistryEnzymeNeuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic SignalingNeurological Complications and Syndromes