Highly Sensitive Determination of Niclosamide Based on The Graphitized and Carboxylated Multi-Walled Carbon Nanotubes Modified Glassy Carbon Electrode
Meimei Guo, Tingting Wu, Gan Zhu, Yunhang Liu, Mengyuan Zhao, Yansheng Shen, Yu Zhou, Lumei Chen, Xiangxing Guo, Qian Wang, Runqiang Liu, Hongyuan Zhao
Abstract
A simple and rapid electrochemical sensor was prepared by using the graphitized and carboxylated multi-walled carbon nanotubes decorated glassy carbon electrode (GR-MWCNTs-COOH/GCE) for the sensitive detection of niclosamide (NA). The carboxylation contributes to the uniform dispersion of MWCNTs because of the good wettability of carboxyl groups. Moreover, the graphitization of MWCNTs could enhance the electrical conductivity of multi-walled carbon nanotubes, which helps provide higher electrochemical response. The obtained GR-MWCNTs-COOH/GCE sensor presented a gratifying limit of detection of 3.1 nM with fitting equation of y=-10.456x+0.566 (R 2 =0.999). Furthermore, the prepared electrochemical sensor has good practical performance with acceptable repeatability and reproducibility for the simple and rapid determination of NA.