MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer
Qiji Li, Min Wang, Yanqing Hu, Ensi Zhao, Jun Li, Liangliang Ren, Meng Wang, Yuandong Xu, Qian Liang, Di Zhang, Yingrong Lai, Shaoyu Liu, Xinsheng Peng, Chengming Zhu, Liping Ye
Abstract
Our results reveal a novel molecular mechanism conferring resistance to ADT and provide a strong rationale for potential therapeutic strategies against CRPC.
Topics & Concepts
Prostate cancerRHOACancer researchMetastasisAndrogen deprivation therapyMedicineBiologyCancerOncologyInternal medicineSignal transductionCell biologyHippo pathway signaling and YAP/TAZProstate Cancer Treatment and ResearchUbiquitin and proteasome pathways