Ligand‐Enabled β‐C(sp<sup>3</sup>)−H Lactamization of Tosyl‐Protected Aliphatic Amides Using a Practical Oxidant
Zhe Zhuang, Shuang Liu, Jin‐Tang Cheng, Kap‐Sun Yeung, Jennifer X. Qiao, Nicholas A. Meanwell, Jin‐Quan Yu
Abstract
Abstract The development of C(sp 3 )−H functionalization reactions that use common protecting groups and practical oxidants remains a significant challenge. Herein we report a monoprotected aminoethyl thioether (MPAThio) ligand‐enabled β‐C(sp 3 )−H lactamization of tosyl‐protected aliphatic amides using tert ‐butyl hydrogen peroxide (TBHP) as the sole oxidant. This protocol features exceedingly mild reaction conditions, reliable scalability, and the use of practical oxidants and protecting groups. Further derivatization of the β‐lactam products enables the synthesis of a range of biologically important motifs including β‐amino acids, γ‐amino alcohols, and azetidines.