Acridine derivatives as inhibitors/poisons of topoisomerase II
Mária Kožurková
Abstract
The potential of acridines (amsacrine) as a topoisomerase II inhibitor or poison was first discovered in 1984, and since then, a considerable number of acridine derivatives have been tested as topoisomerase inhibitors/poisons, containing different substituents on the acridine chromophore. This review will discuss a series of studies published over the course of the last decade, which have investigated various novel acridine derivatives against topoisomerase II activity.
Topics & Concepts
AmsacrineAcridineTopoisomeraseAcridine derivativesChemistryEnzymeBiochemistryStereochemistryOrganic chemistryCancer therapeutics and mechanismsSynthesis and bioactivity of alkaloidsBioactive Compounds and Antitumor Agents