Role of GPR39 in Neurovascular Homeostasis and Disease
Yifan Xu, Anthony P. Barnes, Nabil J. Alkayed
Abstract
GPR39, a member of the ghrelin family of G protein-coupled receptors, is zinc-responsive and contributes to the regulation of diverse neurovascular and neurologic functions. Accumulating evidence suggests a role as a homeostatic regulator of neuronal excitability, vascular tone, and the immune response. We review GPR39 structure, function, and signaling, including constitutive activity and biased signaling, and summarize its expression pattern in the central nervous system. We further discuss its recognized role in neurovascular, neurological, and neuropsychiatric disorders.
Topics & Concepts
Neurovascular bundleHomeostasisNeuroscienceRegulatorBiologyReceptorSignal transductionImmune systemCell biologyImmunologyAnatomyGeneticsGeneRegulation of Appetite and ObesityReceptor Mechanisms and SignalingBiochemical Analysis and Sensing Techniques