Diabetes Mellitus Is a Possible Risk Factor for Nodo-paranodopathy With Antiparanodal Autoantibodies
Luise Appeltshauser, Julia Messinger, Katharina Starz, David Heinrich, Anna-Michelle Brunder, Helena Stengel, Bianca Fiebig, Ilya Ayzenberg, Frank Birklein, Christian Dresel, Johannes Dorst, Florian Dvorak, Alexander Grimm, Alexander Joerk, Frank Leypoldt, Mathias Mäurer, Patrick Merl, Sebastian Michels, Kalliopi Pitarokoili, Mathias T. Rosenfeldt, Anne‐Dorte Sperfeld, M. Weihrauch, Gabriel Simon Welte, Claudia Sommer, Kathrin Doppler
Abstract
Nodo-paranodopathies are peripheral neuropathies with dysfunction of the node of Ranvier. Affected patients who are seropositive for antibodies against adhesion molecules like contactin-1 and neurofascin show distinct clinical features and a disruption of the paranodal complex. An axoglial dysjunction is also a characteristic finding of diabetic neuropathy. Here, we aim to investigate a possible association of antibody-mediated nodo-paranodopathy and diabetes mellitus (DM).