Structure and activity relationship analysis of xanthones from mangosteen: Identifying garcinone E as a potent dual EGFR and VEGFR2 inhibitor
Jingjing Li, Xin Nie, Panthakarn Rangsinth, Xiaoping Wu, Chengwen Zheng, Yanfen Cheng, Polly Ho-Ting Shiu, Renkai Li, Simon Ming‐Yuen Lee, Chaomei Fu, Jinming Zhang, Gph Leung
Topics & Concepts
AngiogenesisIn vivoGarcinia mangostanaChemistryKinase insert domain receptorEpidermal growth factor receptorPharmacologyEx vivoVascular endothelial growth factorEGFR inhibitorsDocking (animal)Cancer researchBiochemistryIn vitroBiologyReceptorVascular endothelial growth factor AVEGF receptorsTraditional medicineMedicineNursingBiotechnologyNatural Compound Pharmacology StudiesPhytochemistry and biological activity of medicinal plantsBioactive Compounds and Antitumor Agents