2,3-Dihydroquinazolin-4(1<i>H</i>)-ones and quinazolin-4(3<i>H</i>)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation
Nicholas S. O’Brien, Jayne Gilbert, Adam McCluskey, Jennette A. Sakoff
Abstract
+ M cell cycle arrest indicative of inhibition of tubulin polymerisation, with 39 inducing an equivalent effect on cell cycle arrest as nocodazole (68).
Topics & Concepts
ChemistryTubulinBroad spectrumCytotoxic T cellCombinatorial chemistryStereochemistryMicrotubuleBiochemistryBiologyIn vitroCell biologyQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity