Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt
Rongjin Sun, Lijun Zhu, Li Li, Wenjie Song, Xia Gong, Xiaoxiao Qi, Ying Wang, Romi Ghose, Song Gao, Ming Hu, Zhongqiu Liu
Topics & Concepts
SN-38IrinotecanBioavailabilityPharmacokineticsActive metaboliteMultidrug resistance-associated protein 2EffluxPharmacologyChemistryDiarrheaInternal medicinePhenytoinMetaboliteGastroenterologyTransporterMedicineATP-binding cassette transporterColorectal cancerCancerBiochemistryPsychiatryGeneEpilepsyCancer therapeutics and mechanismsLung Cancer Research StudiesDrug Transport and Resistance Mechanisms