Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens
Efthymia Papalexi, Eleni P. Mimitou, Andrew Butler, Samantha D. Foster, Bernadette Bracken, William M. Mauck, Hans‐Hermann Wessels, Yuhan Hao, Bertrand Z. Yeung, Peter Smibert, Rahul Satija
Topics & Concepts
BiologyCRISPRComputational biologyImmune systemCellDownregulation and upregulationCell biologyTranscriptional regulationSignal transductionTranscription factorGeneticsGeneSingle-cell and spatial transcriptomicsCRISPR and Genetic EngineeringGene Regulatory Network Analysis