Legionella pneumophila Rhizoferrin Promotes Bacterial Biofilm Formation and Growth within Amoebae and Macrophages
Alberto E. Lopez, Lubov Grigoryeva, Armando Barajas, Nicholas P. Cianciotto
Abstract
Previously, we showed that Legionella pneumophila secretes rhizoferrin, a polycarboxylate siderophore that promotes bacterial growth in iron-deplete media and the murine lung. Yet, past studies failed to identify a role for the rhizoferrin biosynthetic gene ( lbtA ) in L. pneumophila infection of host cells, suggesting the siderophore’s importance was solely linked to extracellular survival.
Topics & Concepts
Legionella pneumophilaMicrobiologyBiologySiderophoreBiofilmLegionellaBacteriaExtracellularVirulenceGeneCell biologyBiochemistryGeneticsLegionella and Acanthamoeba researchHeme Oxygenase-1 and Carbon MonoxideNeutrophil, Myeloperoxidase and Oxidative Mechanisms