The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration
Sam R.J. Hoare
Topics & Concepts
Drug discoveryPotencyDrugComputational biologyChemistryLigand efficiencyLead compoundPharmacologyIn vitroLigand (biochemistry)BioassayDrug developmentCombinatorial chemistryBiophysicsBiochemistryBiologyReceptorGeneticsComputational Drug Discovery MethodsMonoclonal and Polyclonal Antibodies ResearchReceptor Mechanisms and Signaling