The influence of modified molecular (<scp>d</scp>/<scp>l</scp>-serine) chirality on the theragnostics of PAMAM-based nanomedicine for acute kidney injury
Lulu Kong, Di Fan, Lin Zhou, Shaohua Wei
Abstract
to generate fluorescence to diagnose AKI. Subsequently, the anti-inflammatory drug manganese pentacarbonyl bromide (CORM) was loaded in D-SPH to obtain D-SPHC with AKI theragnostic functions. Simultaneously, the D-SPHC fluorescence signal intensity change during the treatment can be used to monitor the recovery process. This study is the first report of chiral materials used in the diagnosis and treatment of AKI.
Topics & Concepts
Acute kidney injuryBiodistributionNanomedicineInflammationMaterials scienceSunitinibFluorescenceKidneyCancer researchNanoparticleMedicineChemistryNanotechnologyBiochemistryCancerInternal medicineIn vitroQuantum mechanicsPhysicsSulfur Compounds in BiologyHeme Oxygenase-1 and Carbon MonoxideMetal-Organic Frameworks: Synthesis and Applications