Biological activity of new amino phospha betaines with C10–C18 alkyl groups
R. R. Davletshin, A. M. Gayneev, Ekaterina A. Ermakova, N. V. Davletshina, Irina V. Galkina, Kamil Ivshin, Marina P. Shulaeva, О. К. Поздеев
Abstract
New amino phospha betaines were obtained by quaternization of potassium salt of amino phosphonate and higher alkyl bromides. The structure of isopropyl (N-dodecyl-N,N- dimethylammoniomethyl)phosphonate was confirmed by single crystal X-ray diffraction. All synthesized compounds demonstrate high antibacterial and antifungal activities.
Topics & Concepts
ChemistryPhosphonateAlkylIsopropylSalt (chemistry)AntifungalPotassiumAmino acidSodium saltMedicinal chemistryStereochemistryOrganic chemistryInorganic chemistryBiochemistryMicrobiologyBiologyOrganophosphorus compounds synthesisSynthesis and Characterization of Heterocyclic CompoundsSynthesis and Reactivity of Sulfur-Containing Compounds