Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis
Liangqi Chen, Meiju Zhang, Xueyan Yang, Yanan Wang, Tuo Huang, Xin Li, Yunting Ban, Qifeng Li, Qingyuan Yang, Yongxiang Zhang, Zheng Yang, Di Wang, Xiaoqi Wang, Xiujie Shi, Maomao Zhang, Yonghua Sun, Jian Wu
Abstract
These findings reveal a novel mechanism by which exercise ameliorates atherosclerosis via MeCP2 K271 lactylation-H3K36me3/RUNX1. Interventions that enhance MeCP2 K271 lactylation have been shown to increase pro-repair M2 macrophage infiltration, thereby promoting plaque stabilization and reducing the risk of atherosclerotic cardiovascular disease. We also established RUNX1 as a potential drug target for exercise therapy, thereby providing guidance for the discovery of new targets.
Topics & Concepts
Macrophage polarizationMacrophageChemistryCpG siteCell biologyCancer researchBiophysicsMedicineBiologyIn vitroBiochemistryDNA methylationGene expressionGeneImmune cells in cancerPhagocytosis and Immune RegulationMacrophage Migration Inhibitory Factor