Thermally induced silane dehydrocoupling on porous silicon nanoparticles for ultra-long-acting drug release
Ji Hyeon Oh, Rae Hyung Kang, Jaehoon Kim, Eun‐Kyoung Bang, Dokyoung Kim
Abstract
Here, we report an ultra-long-acting drug release nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared by thermally induced silane dehydrocoupling and lipid-coating. This robust formulation offers the ability to release an anticancer drug, for up to 2 weeks, in various biological environments; pH 7.4 buffer, cancer cells, and tumor xenograft model.
Topics & Concepts
SilaneMaterials scienceCoatingPorous siliconNanoparticleSiliconAmphiphilePorosityChemical engineeringNanotechnologyDrugCopolymerPolymerComposite materialOptoelectronicsPsychiatryEngineeringPsychologySilicon Nanostructures and PhotoluminescenceNanowire Synthesis and ApplicationsMechanical and Optical Resonators