Domino Sonogashira coupling/metal carbene-involved annulation enabled by Pd/Cu relay catalysis: rapid assembly of indazole-containing biheteroaryls
Ruiming Ding, Haili Cui, Yongyan Zhu, Yao Zhou, Huaming Tao, Shaoyu Mai
Abstract
An efficient and novel method has been developed for the synthesis of indazole-containing biheteroaryls via a domino Sonogashira coupling/azaenyne cycloisomerization/Barton–Kellogg reaction.
Topics & Concepts
Sonogashira couplingIndazoleChemistryDominoCycloisomerizationCombinatorial chemistryAnnulationCatalysisCascade reactionCarbenePalladiumPhotochemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions