Circulating Activated Platelets in Children With Long COVID: A Case-Controlled Preliminary Observation
Danilo Buonsenso, Silvia Sorrentino, Antonietta Ferretti, Rosa Morello, Piero Valentini, Leonardo Di Gennaro, Erica De Candia
Abstract
We investigated if children with Long COVID (n=14) have activated platelets compared with healthy controls (n=14). Platelet activation and secretion markers were investigated by flow cytometry using MoAbs directed against P-selectin, CD63, and PAC-1 in quiescent platelets and in platelets stimulated with 10-µM adenosine diphosphate and 25-µM protease activated receptor 1-activating peptide. Circulating platelets of patients with Long COVID had significantly increased expression of the activation marker cytometry using MoAbs directed against P-selectin ( P = 0.019).
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Platelet2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyPlatelet activationMedicineImmunologyInternal medicineOutbreakInfectious disease (medical specialty)DiseaseLong-Term Effects of COVID-19Obstructive Sleep Apnea ResearchCOVID-19 Clinical Research Studies