Predictors of Hospitalization for Manic Episode in Alzheimer’s Dementia: Inputs From an Inpatient Case-Control Study
Varsha Nandwana, Jaskaranpreet Kaur, Ripudaman Singh, Sanobar Jaka, Gagan Kaur, Era Rawal, Keerthika Mathialagan, Ozge C. Amuk Williams
Abstract
percentile (63%). Females were more likely to be hospitalized for manic episodes (OR 1.33; 95% CI 1.09-1.64) than males. AD inpatients with manic episodes had a higher risk of presenting with suicidal behaviors (OR 1.88; 95% CI 1.23-2.86). A significantly higher proportion of AD inpatients with manic episodes had comorbid tobacco use (5.3% vs. 3.4%) and cannabis use (1.4% vs. 0%) compared to those without manic episodes. Conclusion Females with AD had a greater risk of being hospitalized for manic episodes. These patients have an 88% higher risk of suicidal behaviors during the manic presentation and have comorbid tobacco and cannabis use. Early diagnosis and management of manic episodes in at-risk AD patients are important to improve the quality of life (QoL) and outcomes.