Thrombotic Microangiopathy in Pregnancy: Current Understanding and Management Strategies
Manuel Urra, Shannon Lyons, Corina Gabriela Teodosiu, Richard M. Burwick, Anuja Java
Abstract
Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by microvascular thrombosis and end-organ damage. Pregnancy-associated thrombotic microangiopathy (p-TMA) has emerged as a distinct clinical entity with unique diagnostic challenges. Identifying the specific form of p-TMA is critical for appropriate and timely management. This review offers a comprehensive overview of the various forms of thrombotic microangiopathies associated with pregnancy, highlighting our current understanding of their pathophysiology and the evolving landscape of diagnosis and treatment for each.
Topics & Concepts
MedicineThrombotic microangiopathyPregnancyCurrent (fluid)MicroangiopathyIntensive care medicineObstetricsInternal medicineEndocrinologyGeneticsDiabetes mellitusBiologyElectrical engineeringEngineeringDiseaseComplement system in diseasesNeurological Complications and SyndromesBlood Coagulation and Thrombosis Mechanisms