N-Type Ca Channel in Epileptic Syndromes and Epilepsy: A Systematic Review of Its Genetic Variants
Sonia Mayo, Irene Gómez-Manjón, Ana Victoria Marco Hernández, Francisco Javier Fernández‐Martínez, Ana Camacho, Francisco Martı́nez
Abstract
N-type voltage-gated calcium channel controls the release of neurotransmitters from neurons. The association of other voltage-gated calcium channels with epilepsy is well-known. The association of N-type voltage-gated calcium channels and pain has also been established. However, the relationship between this type of calcium channel and epilepsy has not been specifically reviewed. Therefore, the present review systematically summarizes existing publications regarding the genetic associations between N-type voltage-dependent calcium channel and epilepsy.
Topics & Concepts
EpilepsyCalcium channelVoltage-dependent calcium channelT-type calcium channelN-type calcium channelNeuroscienceGenetic associationCalciumVoltage-gated ion channelMedicineBiologyBioinformaticsGeneticsIon channelInternal medicineGeneReceptorSingle-nucleotide polymorphismGenotypeIon channel regulation and functionNeuroscience and Neuropharmacology ResearchEpilepsy research and treatment