Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19
Younes Zaid, Fadila Guessous, Florian Puhm, Wail Elhamdani, Lamyae Chentoufi, Andrew Conway Morris, Amine Cheikh, Farid Jalali, Éric Boilard, Louis Flamand
Abstract
In addition to preserving homeostasis and contributing to immunity, platelets may exhibit a dysregulated state in acute respiratory distress syndrome (ARDS), and potentially exacerbate lung injury. Although thrombocytopenia has been associated with increased mortality in ARDS and particularly in H1N1 influenza-infected patients, analysis of quantitative changes in platelet activation levels in ARDS, and how these may differ between the various etiologies of ARDS remains limited.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)ARDS2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PlateletThrombinBetacoronavirusVirologyThrombin generationMedicineCoronavirus InfectionsImmunologyInternal medicineLungOutbreakDiseaseInfectious disease (medical specialty)COVID-19 Clinical Research StudiesVenous Thromboembolism Diagnosis and ManagementInflammatory Biomarkers in Disease Prognosis