Preparation of a Multifunctional Wound Dressing Based on a Natural Deep Eutectic Solvent
Yilei Wang, Yingbin Zhang, Jianmin Su, Xiaoli Zhang, Jinyi Wang, Qin Tu
Abstract
Improving the performance of skin wound dressings is still a research topic receiving widespread clinical and medical attention. An ideal wound dressing should have robust physical and biological properties. Inspired by the green chemistry concept of natural deep eutectic solvents (NADESs), we report a simple and environmentally friendly method to construct an excellent multifunctional wound dressing hydrogel based on an NADES first. In vitro experiments showed that the hydrogel had outstanding cell compatibility and antibacterial properties. Meanwhile, the mouse model skin damage experiment showed that the hydrogel strongly promoted wound healing (nearly 100% skin recovery in 9 d, which is better than other wound dressing materials that have been reported). To our knowledge, the hydrogel represents the first promising wound dressing constructed based on an NADES, which can be applied to the medical material in the future.