The protective role of microbiota in the prevention of MPTP/P-induced Parkinson's disease by resveratrol
Jing Tao, Yunying An, Lingyun Xu, Yuxin Wang, Chaowei Wang, Puze Li, Min Li, Dong Yan, Mingyong Wang, Genshen Zhong, Minna Wu
Abstract
. Therefore, results in this study demonstrated that gut microbiota played a vital role in the prevention of PD progression, and the shaping of the gut microbiota was the pharmacological mechanism of resveratrol in alleviating the phenotype of Parkinson's disease in PD mice.
Topics & Concepts
MPTPResveratrolSubstantia nigraTyrosine hydroxylaseParkinson's diseasePars compactaGut floraStriatumPharmacologyMedicineParkinsonismInternal medicineDopamineEndocrinologyImmunologyDiseaseGut microbiota and healthTryptophan and brain disordersParkinson's Disease Mechanisms and Treatments