Quality by design approach for formulation development and evaluation of carboplatin loaded ethylcellulose nanosponges
Muhammad Ahsan Hafiz, Nasir Abbas, Nadeem Irfan Bukhari
Abstract
Nanosponges, porous nanocarriers were explored for encapsulation of carboplatin by employing a quality by design approach. Nanosponges were prepared by double emulsion solvent evaporation using the central composite design. Ethylcellulose, 450 mg, polyvinyl alcohol, 2.3% (w/v) and phase evaporation rate, 760 rpm yielded the optimized spherical particles of size 272.92 ± 12.31 nm, PDI 0.390, with zeta charge of −22.3 mV. The entrapment efficiency of carboplatin-loaded nanosponges was 56.27 ± 2.52%. A sustained carboplatin release of 79.03% and 95.94% within 12 h at pH 4.5 and 6.8, respectively suggested that nanosponges could be promising carriers for sustained release of hydrophilic therapeutic candidates.