Transcription of the Alginate Operon in Pseudomonas aeruginosa Is Regulated by c-di-GMP
Ziwei Liang, Morten Rybtke, Kasper Nørskov Kragh, O. W. Johnson, Muriel Leandra Schicketanz, Yong Everett Zhang, Jens Bo Andersen, Tim Tolker‐Nielsen
Abstract
The proliferation of alginate-overproducing P. aeruginosa variants in the lungs of cystic fibrosis patients often leads to chronic infection. The alginate functions as a biofilm matrix that protects the bacteria against host immune defenses and antibiotic treatment.
Topics & Concepts
OperonPseudomonas aeruginosaTranscription (linguistics)Geneticsgal operonPseudomonadalesBiologyComputational biologyMicrobiologyGeneBacteriaEscherichia coliLinguisticsPhilosophyBacterial biofilms and quorum sensingLegionella and Acanthamoeba researchCancer Research and Treatments