Resistance to anti-epidermal growth factor receptor in metastatic colorectal cancer: What does still need to be addressed?
Giulia Martini, Davide Ciardiello, Pietro Paolo Vitiello, Stefania Napolitano, Claudia Cardone, Antonio Cuomo, Teresa Troiani, Fortunato Ciardiello, Erika Martinelli
Topics & Concepts
PanitumumabCetuximabMedicineColorectal cancerEpidermal growth factor receptorPTENGrowth factor receptorMAPK/ERK pathwayOncologyKRASCancer researchInternal medicineTargeted therapyCancerEpidermal growth factorReceptorPI3K/AKT/mTOR pathwaySignal transductionBiologyBiochemistryColorectal Cancer Treatments and StudiesMelanoma and MAPK PathwaysLung Cancer Treatments and Mutations