In Situ Programming of CAR T Cells
Neha N. Parayath, Matthias T. Stephan
Abstract
Gene therapy makes it possible to engineer chimeric antigen receptors (CARs) to create T cells that target specific diseases. However, current approaches require elaborate and expensive protocols to manufacture engineered T cells ex vivo, putting this therapy beyond the reach of many patients who might benefit. A solution could be to program T cells in vivo. Here, we evaluate the clinical need for in situ CAR T cell programming, compare competing technologies, review current progress, and provide a perspective on the long-term impact of this emerging and rapidly flourishing biotechnology field.
Topics & Concepts
Chimeric antigen receptorFlourishingCell therapyGenetic enhancementEx vivoPerspective (graphical)BiologyComputer scienceComputational biologyImmunologyStem cellIn vivoT cellBiotechnologyCell biologyImmune systemGeneArtificial intelligencePsychologyGeneticsPsychotherapistCAR-T cell therapy researchNanowire Synthesis and ApplicationsViral Infectious Diseases and Gene Expression in Insects