Sulforaphane inhibits the production of Aβ partially through the activation of Nrf2-regulated oxidative stress
Shunxi Zhang, Jiahe Zhao, Zhihuai Bai, Lina Luo, Fan Wu, Bao‐Long Li, Yujuan Shan
Abstract
) decreased the escape latency (24.96 ± 7.43 s) and increased the target-zone frequency (3.19 ± 1.19) in rats. SFN improved the pathological morphology and the number of neurons in the hippocampus. Additionally, SFN significantly upregulated the contents of thioredoxin and glutathione as well as the activities of antioxidant enzymes, along with the expression of the Nrf2 protein. Conversely, SFN lowered the Aβ content and ROS level in N2a/APP cells. After silencing the Nrf2 by SiRNA, the inhibitory effects of SFN on ROS and Aβ production were partially weakened. In conclusion, the improvement of AD by SFN was closely related with Nrf2 activation.
Topics & Concepts
SulforaphaneOxidative stressChemistryOxidative phosphorylationCell biologyBiochemistryBiologyGenomics, phytochemicals, and oxidative stressAluminum toxicity and tolerance in plants and animalsSelenium in Biological Systems