Feline Calicivirus Proteinase-Polymerase Protein Degrades mRNAs To Inhibit Host Gene Expression
Hongxia Wu, Jiapei Huang, Yongxiang Liu, Yudi Pan, Li Yin, Qian Miao, Liandong Qu, Jin Tian
Abstract
assay showed that the GST-PP fusion protein possesses RNase activity in the absence of other viral or cellular proteins. This study demonstrates that FCV induces host gene shutoff by promoting the degradation of host mRNAs, thereby introducing a potential mechanism by which FCV infection inhibits the immune response.
Topics & Concepts
BiologyFeline calicivirusGene expressionViral replicationMolecular biologyMessenger RNAGeneViral proteinRNARNase PVirusVirologyGeneticsViral gastroenteritis research and epidemiologyAnimal Virus Infections StudiesViral Infections and Immunology Research