Quantification of Available Ligand Density on the Surface of Targeted Liposomal Nanomedicines at the Single-Particle Level
Chaoxiang Chen, Yingxing Zhou, Chen Chen, Shaobin Zhu, Xiaomei Yan
Abstract
for folate-, transferrin-, and HER2-antibody-conjugated liposomes, respectively. These optimal values agreed well with the spike density of the natural counterparts, viruses. The as-developed approach is generally applicable to a wide range of active-targeting nanocarriers.
Topics & Concepts
LiposomeMaterials scienceNanotechnologyParticle (ecology)Ligand (biochemistry)ChemistryReceptorBiologyEcologyBiochemistryNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched PolymersGold and Silver Nanoparticles Synthesis and Applications