Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain
Gerti Beliu, Steffen Altrichter, Ramón Guixà-González, Mareike Hemberger, Ina Brauer, Anne-Kristin Dahse, Nicole Scholz, Robert Wieduwild, Alexander Kuhlemann, Hossein Batebi, Florian Seufert, Guillermo Pérez‐Hernández, Peter W. Hildebrand, Markus Sauer, Tobias Langenhan
Topics & Concepts
G protein-coupled receptorAgonistBiologyCell biologyReceptorFlexibility (engineering)Cell adhesionHEK 293 cellsProtein subunitSignal transductionBiophysicsAdhesionNeuroscienceCellBiochemistryChemistryGeneOrganic chemistryStatisticsMathematicsReceptor Mechanisms and SignalingMonoclonal and Polyclonal Antibodies ResearchMass Spectrometry Techniques and Applications