The influence of a tomato food matrix on the bioavailability and plasma kinetics of oral gamma-aminobutyric acid (GABA) and its precursor glutamate in healthy men
Tessa H. de Bie, Michiel G.J. Balvers, Ric C. H. de Vos, Renger F. Witkamp, Maarten A. Jongsma
Abstract
= 0.006). These data suggest that GABA is bioavailable from tomatoes, and that food products containing GABA could potentially induce health effects similar to those claimed for GABA supplements. The results merit further studies on the bioavailability of GABA from other food products and the health effects of GABA-rich diets. The clinical trial registry number is NCT04086108 (https://clinicaltrials.gov/ct2/show/NCT04303468).
Topics & Concepts
Bioavailabilitygamma-Aminobutyric acidGlutamate receptorKineticsChemistryMatrix (chemical analysis)Plasma concentrationFood sciencePlasmaBiochemistryChromatographyPharmacologyBiologyQuantum mechanicsPhysicsReceptorGABA and Rice ResearchBiochemical effects in animalsBiochemical Analysis and Sensing Techniques