Global monkeypox case hospitalisation rates: A rapid systematic review and meta-analysis
Michael DeWitt, Christopher Polk, John Williamson, Avinash K. Shetty, Catherine Passaretti, Candice J. McNeil, Robert T. Fairman, Mindy Sampson, Cynthia Dalton, John W. Sanders
Abstract
Background: Estimates of the case hospitalization rate and case fatality rate when hospital care is available for monkeypox (MPX) infections have not been well defined. This rapid systematic review and meta-analysis aimed to estimate the case hospitalisation rate and case fatality rate where hospital care is available. Methods: . Findings: 99.9%), with evidence of large heterogeneity between the studies. Interpretation: There is limited data for MPX hospitalization rates in countries where MPX has been traditionally non-endemic until the current outbreak. Due to substantial heterogeneity, caution is needed when interpreting these findings. Health care organizations should be cognizant of the potential increase in healthcare utilization. Rapid identification of infection and use of appropriate therapies such as antivirals play a role reducing the CHR and associated CFR. Funding: None.