Targeting G-quadruplexes in an ageing epigenetic regulator promoter for rescuing mitochondrial dysfunction in Alzheimer's disease
Jie Yang, Geng Qin, Jingsheng Niu, Wei Yue, Xuexia Li, Chuanqi Zhao, Chunyu Wang, Jinsong Ren, Xiaogang Qu
Abstract
Here, we provide an out-of-the-box G-quadruplex (G4) targeting-based strategy for rescuing mitochondrial dysfunction in Alzheimer's disease. We predict and verify the presence of G4s within the promoter of an ageing epigenetic regulator BAZ2B. G4-specific ligands targeting BAZ2B G4s could significantly down-regulate the BAZ2B expression and relieve mitochondrial dysfunction. Therefore, this work may provide a new way of rescuing mitochondrial dysfunction in AD by targeting G4s in a specific ageing epigenetic regulator promoter.
Topics & Concepts
EpigeneticsRegulatorAgeingBiologyMitochondrionPromoterCell biologyMitochondrial DNAMaster regulatorGeneticsGeneGene expressionTranscription factorDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery