Lithium amide catalyzed hydroboration of nitriles
Pradip Ghosh, Axel Jacobi von Wangelin
Abstract
An operationally facile hydroboration of nitriles is reported that utilizes the stable and inexpensive catalyst LiN(SiMe<sub>3</sub>)<sub>2</sub>. The reaction displayed good tolerance of functional groups and also converted carbonyl derivatives.
Topics & Concepts
HydroborationChemistryAmideCatalysisLithium amideLithium (medication)Organic chemistryNitrileFunctional groupCombinatorial chemistryEnantioselective synthesisEndocrinologyPolymerMedicineOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions