Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships
Qian Xie, Yanni Shen, Yanli Meng, Jianhui Liang, Jing Xu, Shishao Liang, Xiaoping Liu, Yan Wang, Chun Hu
Topics & Concepts
ChemistryMAPK/ERK pathwayPyrimidineApoptosisCytotoxicitySignal transductionCell growthPyrimidine metabolismCytotoxic T cellCancer researchCancer cellPharmacologyCancerStereochemistryBiochemistryIn vitroPurineEnzymeBiologyInternal medicineMedicineMelanoma and MAPK PathwaysCytokine Signaling Pathways and InteractionsSynthesis and biological activity