Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment
Галина Ф. Махаева, Sofya V. Lushchekina, N. V. Kovaleva, T. Yu. Astakhova, Natalia P. Boltneva, Елена В. Рудакова, Olga G. Serebryakova, Alexey N. Proshin, И. В. Серков, Т. П. Трофимова, В. А. Тафеенко, Eugene V. Radchenko, Vladimir A. Palyulin, Владимир Петрович Фисенко, Jan Korábečný, Ondřej Soukup, Rudy J. Richardson
Topics & Concepts
ButyrylcholinesteraseChemistryAcetylcholinesterasePiperazineAchéStereochemistryLead compoundCholinesteraseEnzymeBiochemistryPharmacologyIn vitroOrganic chemistryMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity