The serotonin reuptake transporter is reduced in the epithelium of active Crohn’s disease and ulcerative colitis
Jonas Woll Jørandli, Silje Thorsvik, Helene Kolstad Skovdahl, Benedikt Kornfeld, Siri Sæterstad, Björn Gustafsson, Arne K. Sandvik, Atle van Beelen Granlund
Abstract
The serotonin reuptake transporter is potently reduced in inflamed areas of Crohn's ileitis, Crohn's colitis, and ulcerative colitis. The changes are localized to the intestinal epithelium and can be induced by TNF-α. The serotonin synthesis through tryptophan hydroxylase 1 is unchanged. This regulation is suggested as a mechanism underlying the increased extracellular serotonin levels associated with intestinal inflammation.
Topics & Concepts
Serotonin transporterUlcerative colitisSerotoninIleitisSerotonin Plasma Membrane Transport ProteinsReuptakeIntestinal epitheliumColitisInternal medicineMedicineGastroenterologyEndocrinologyCrohn's diseaseEpitheliumDiseasePathologyReceptorGastrointestinal motility and disordersGut microbiota and healthTryptophan and brain disorders