Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan
Mohammed Alwatban, Stacey E. Aaron, Carolyn S. Kaufman, Jill N. Barnes, Patrice Brassard, Jaimie L. Ward, Kathleen B. Miller, Anna J. Howery, Lawrence Labrecque, Sandra A. Billinger
Abstract
= 524) pooled from three institutions to study how age and sex affect middle cerebral artery blood velocity (MCAv) and flow pulsatility index (PI) across the adult lifespan. We report the rate of MCAv decline and flow PI rise is significantly greater in females compared with in males. These data suggest that sex-specific trajectories with aging and therapeutic interventions to promote healthy brain aging should consider these findings.
Topics & Concepts
Middle cerebral arteryPulsatility indexMedicineBlood flowDemographyInternal medicineCerebral blood flowCardiologyBiologyIschemiaPregnancyFetusGeneticsSociologyCardiovascular Health and Disease PreventionCerebrovascular and Carotid Artery DiseasesAcute Ischemic Stroke Management