Mechanistic Insights into the Activation of Lecithin–Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids
Laura Giorgi, Akseli Niemelä, Esa‐Pekka Kumpula, Ossi Natri, Petteri Parkkila, Juha T. Huiskonen, Artturi Koivuniemi
Abstract
ability to promote LCAT-mediated cholesterol esterification.
Topics & Concepts
Antiparallel (mathematics)PeptideChemistryLecithin—cholesterol acyltransferaseLecithinApolipoprotein BBiochemistryLysineBiophysicsCholesterolAmino acidBiologyPhysicsQuantum mechanicsMagnetic fieldGlycosylation and Glycoproteins ResearchCaveolin-1 and cellular processesLipid Membrane Structure and Behavior