Engineered RAP-anchored copper-escorting liposomes for FDX1-targeted cuproptosis in glioblastoma therapy
Mengmeng Liu, Lingxiao Zhao, Zhiqiang Gong, Yao He, Xue Jiang, Wei Luo, Xin Yu, Zhan‐You Wang
Abstract
This study successfully constructed RAP-LPs@ESCu which selectively eliminated mitochondria-metabolically active GBM cells via an FDX1-dependent cuproptosis pathway, ultimately achieving orthotopic GBM growth suppression.
Topics & Concepts
GlioblastomaLiposomeCopperCancer researchMedicineNanotechnologyMaterials scienceMetallurgyNanoparticle-Based Drug DeliveryMicroRNA in disease regulationExtracellular vesicles in disease