Synthesis of new Pyridazinone derivatives and their dual inhibitory activity on aldose reductase and α-glucosidase
Mevlüt Akdağ, Merve Çam, Derya Ergen, Yeliz Demir, Şükrü Beydemir, Azime Berna Özçelik
Topics & Concepts
Aldose reductaseChemistryAldehyde ReductaseEnzymePolyol pathwayStereochemistryInhibitory postsynaptic potentialIn vitroBiochemistryPharmacologyPostprandialDrugLead compoundDocking (animal)Structure–activity relationshipAldose reductase inhibitorActive siteEnzyme inhibitorAldoseChemical synthesisIsostereReductaseRational designDiabetes mellitusBiological activityBinding siteCombinatorial chemistryPolyolType 2 Diabetes MellitusGlycationDrug designImideAldose Reductase and TaurineEnzyme function and inhibitionNatural Antidiabetic Agents Studies