Cigarette Smoke Extract-Treated Mouse Airway Epithelial Cells-Derived Exosomal LncRNA MEG3 Promotes M1 Macrophage Polarization and Pyroptosis in Chronic Obstructive Pulmonary Disease by Upregulating TREM-1 via m<sup>6</sup>A Methylation
Lijing Wang, Qiao Yu, Jian Xiao, Qiong Chen, Min Fang, Hongjun Zhao
Abstract
further aggravated lung injury, M1 polarization, and pyroptosis, which were reversed by MEG3 inhibition. TREM-1 overexpression negated the palliative effects of MEG3 inhibition on COPD mouse lung injury. Collectively, CSE-treated MAECs-derived exosomal long non-coding RNA MEG3 may expedite M1 macrophage polarization and pyroptosis in COPD via the SPI1/METTL3/TREM-1 axis.
Topics & Concepts
PyroptosisMacrophage polarizationCOPDMedicineMicrovesiclesCancer researchMacrophageImmunologyReceptorChemistryInternal medicinemicroRNAIn vitroGeneInflammasomeBiochemistryInflammation biomarkers and pathwaysExtracellular vesicles in diseaseInflammasome and immune disorders