Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities
Karl Petri, Elvira D’Ippolito, Annette Künkele, Ulrike Koehl, Dirk H. Busch, Hermann Einsele, Michael Hudecek
Topics & Concepts
CRISPRGenome editingComputational biologyChimeric antigen receptorImmunotherapyT cellCancer immunotherapyGenetic enhancementTranscription activator-like effector nucleaseBiologyImmune systemAntigenGeneTransgeneComputer scienceMedicineCancerBioinformaticsCas9GenomeGenome engineeringCancer researchGenetically modified organismClinical trialSynthetic biologyCell therapyViral vectorCAR-T cell therapy researchCRISPR and Genetic EngineeringVirus-based gene therapy research