Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation
Yi Li, Yuchen Li, Xiao-Tian Liu, Lu Zhang, Yi-Hua Chen, Qiong Zhao, Wen Gao, Baolin Liu, Hua Yang, Ping Li
Abstract
content to ensure mitochondrial biogenesis for oxidative phosphorylation. Furthermore, blockage of citrate export reduces cerebral thrombosis by inactivation of peripheral macrophages.
Topics & Concepts
Citric acid cycleFragmentation (computing)ChemistryCell biologyCitric acidBiochemistryBiologyMetabolismEcologyCancer, Hypoxia, and MetabolismMitochondrial Function and PathologyAmino Acid Enzymes and Metabolism