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Sacubitril/valsartan alleviates sunitinib-induced cardiac fibrosis and oxidative stress via improving TXNIP/TRX system and downregulation of NF-ĸB/Wnt/β-catenin/SOX9 signaling

Hoda E. Mohamad, Mervat E. Askar, Mohamed A. Shaheen, Nourhan M. Baraka, Yasmin K. Mahmoud

2024International Immunopharmacology11 citationsDOI

Topics & Concepts

TXNIPValsartanOxidative stressSunitinibMedicineWnt signaling pathwayThioredoxin-Interacting ProteinPharmacologyCancer researchRANKLDownregulation and upregulationEndocrinologyInternal medicineChemistryThioredoxinSignal transductionCancerBlood pressureBiochemistryActivator (genetics)GeneReceptorInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisCardiac Fibrosis and RemodelingChemotherapy-induced cardiotoxicity and mitigation
Sacubitril/valsartan alleviates sunitinib-induced cardiac fibrosis and oxidative stress via improving TXNIP/TRX system and downregulation of NF-ĸB/Wnt/β-catenin/SOX9 signaling | Litcius