Visible-Light-Driven, Palladium-Catalyzed Heck Reaction of Internal Vinyl Bromides with Styrenes
Yunlong Li, Haibo Liu, Zilong Huang, Yuan He, Bao‐Hua Xu, Hongmei Wang, Zhengkun Yu
Abstract
Functionalized 1,3-dienes were efficiently accessed from visible-light-driven, palladium-catalyzed Heck reaction of S,S-functionalized internal vinyl bromides with styrenes under mild conditions. This Heck reaction showcased tolerance of a wide array of functional groups, afforded the target products in moderate to excellent yields through a radical reaction pathway. The resultant diene products could be further transformed to highly functionalized trisubstituted furan derivatives.
Topics & Concepts
PalladiumHeck reactionFuranCatalysisChemistryDieneOrganic chemistryReaction conditionsPhotochemistryCombinatorial chemistryNatural rubberSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods